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. Author manuscript; available in PMC: 2020 Oct 15.
Published in final edited form as: Anal Chem. 2019 Sep 26;91(20):13206–13212. doi: 10.1021/acs.analchem.9b03640

Figure 3.

Figure 3.

Histograms showing the distribution of PTP activities in individual cells from a population, with corresponding fits to a gamma distribution. A control experiment where no cells were added to the wells (48 wells, gray) reveals a background level of measured activity. An experiment to measure activities in individual cells reveals a broad distribution (143 single cells, blue), and a control experiment that measures activities in an identical homogenous lysate (96 wells, pink) reveals the technical variance in the assay, and demonstrates that a significant fraction of the distribution in the analysis of a cell population is due to variation in PTP activity.