Table 1.

IC₅₀ values, or percentage of inhibition at 200 μM, of MC4040 and MC4041 against a panel of methyltransferases

Compound	IC50, μMa or % inhibition at 200 μM
	EZH2	EZH1	G9a	PRMT1	DNMT1
MC4040	4.06	42.7	NAb	NA	NA
MC4041	1.06	10.6	NA	11.9%	NA
SAH	34.7
GSK126	0.009
TAZc	<0.005

^aPerformed in a 10-dose IC₅₀ mode with 2-fold serial dilution starting from 200 μM. ^bNA, not active. ^cTAZ, tazemetostat