Table 3.
Comparison between viral vectors versus lipid nanoparticles focused on dimension, carrying and spreading capacity, oncolytic effect, and pathogenicity.
| Characteristics | Carrier |
||||
|---|---|---|---|---|---|
| Viruses |
Nanoparticles |
||||
| adenoviruses | HSVs | Retroviruses | AAVs | Lipid nanoparticles | |
| Dimension | 100–200 nm | 20 nm | |||
| Carrying capacity | + | ++ | +/- | - | +/- |
| Dimension of carried genetic material | >5Kb | >40 KB | 10-15 Kb | <<5 kb | +/- |
| Spreading capacity | +/- | - - | + | + | - |
| Oncolytic effect in disseminated tumors | +/- | - | +/- | - - | +/- |
| Pathogenicity vs. Host | ++ | ++ | +/- | +/- | - - |
HSVs: herpes simplex viruses; AAVs: adeno-associated viruses; “++”: very high; “+”: high; “+/-”: medium; “-”: low; “- -”: very low.