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. 2019 Dec 2;10:5498. doi: 10.1038/s41467-019-13465-y

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Fig. 4 — Transgenic expression of Myc in TEC drives thymic growth. a Total thymus counts of WT (white bars) or FoxN1MycTg (gray bars) mice at embryonic day 14.5 (E14.5), newborn (NB) or 4 weeks of age. b Photographs of 10-week-old thymi from WT (left) or FoxN1MycTg (right) mice. c Representative flow plots of the frequency of CD45⁻ EpCAM⁺ total TEC (above), or Ly51⁺ UEA⁻ cTEC and Ly51⁻ UEA⁺ mTEC pre-gated on CD45⁻ EpCAM⁺ total TEC (below), from 4-week-old WT or FoxN1MycTg mice. Bar graphs display the frequency (above) or cell number (below) of total TEC (left), cTEC (middle) or mTEC (right) of adult WT or FoxN1MycTg mice. d Representative flow plots of CD80⁺ ClassII⁺ mTEC^hi or CD80⁻ClassII^low mTEC^low, pre-gated on Ly51⁻ UEA⁺ mTEC, or histograms displaying the frequency of Aire⁺ and Aire⁻ cells pre-gated on CD80⁺ ClassII⁺ mTEC^hi from WT or FoxN1MycTg mice. Bar graphs display the frequency (above) or numbers (below) of the corresponding populations. All bar graphs show mean ± SEM for a minimum n = 3 mice per genotype. A two-tailed unpaired Student’s t test was performed to determine significance. *p < 0.05, **p < 0.01, ****p < 0.0001. The source data underlying (a), (c), (d) are provided as a Source Data file.