Fig. 1.

ATM deficiency is associated with PARP inhibitor sensitivity in lung adenocarcinoma cell lines described in the GDSC project. a, b Boxplots comparing olaparib IC₅₀ values between (a) ATM mutant and ATM wild-type cells and (b) ATM amplified and ATM diploid cells. Cell lines containing >3 copies of the ATM gene were classified as “ATM amplified”. c Scatterplot showing the correlation between ATM gene expression (mRNA) and olaparib IC₅₀ values. d–f ATM deficiency is associated with talazoparib sensitivity in 59 lung adenocarcinoma cell lines in the GDSC project. Boxplots comparing talazoparib IC₅₀ values between (d) ATM mutant and ATM wild-type cells; e ATM amplified and ATM diploid cells. f Scatterplot showing the correlation between ATM gene expression and talazoparib IC₅₀ values