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. 2019 Mar 4;26(11):2400–2415. doi: 10.1038/s41418-019-0309-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Aberrant nuclear localization of MEK and high expression of YAP in colon cancers. a TMA analysis of cytoplasmic and nuclear MEK expression in clinical samples of normal and colonl cancer tissues. IHC scores were showed in the left graph. The method assigning IHC scores for each sample was described in ‘Materials and methods' section. The bar graph (right) indicates the percentage of samples, ***p < 0.001. b Representative pictures of MEK staining in clinical samples of normal and colon cancer tissues with different pathological grading. Scale bar: 100/15 μm. c TMA analysis of YAP expression in normal and colon cancer tissues. IHC scores were showed in the left graph. The method assigning IHC scores for each sample was described in ‘Materials and methods' section. The bar graph (right) indicates the percentage of samples, ***p < 0.001. d Representative pictures of normal and colon cancer tissues stained for YAP. Scale bar: 100/15 μm. e Representative pictures of MEK and YAP staining in colon cancer tissues with different expression of nuclear MEK and YAP. Scale bar: 100/15 μm