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Occurrence of mutations sorted by functional annotation among EC prognostic subtypes (Median number of alteration/group).
| Molecular group (variants/group) | ||||
|---|---|---|---|---|
| POLE | MSI | CNL | CNH | |
| Regulator | 11.0 | 5.7 | 6.9 | 4.8 |
| Frameshift | 6.4 | 3.3 | 2.5 | 2.0 |
| In frame | 3.3 | 2.9 | 2.8 | 2.0 |
| Splicing events | 9.3 | 5.1 | 4.6 | 3.8 |
| Synonymous | 24.5 | 13.1 | 14.5 | 9.5 |
| Intron Variant | 13.5 | 8.7 | 10.0 | 6.9 |
| Nonsense | 3.9 | 0.8 | 0.8 | 0.5 |
| Missense | 35.2 | 11.4 | 10.5 | 9.0 |
