Fig. 2.

Alignment of Plasmodium falciparum falcipain and human cathepsin proteases. Sequence alignment of mature parasite falcipain and human cathepsin proteases. Sequence numbering derives from UniProt entries as described in “Methods”. Darker blue shading denotes increased conservation for a given amino acid position. Above alignments asterisks mark residues of the catalytic dyad, and crosses mark non-conserved and similar residues in the vicinity of the EC48 binding site (coloured light brown and grey in Fig. 1h). Below alignments arrowheads denote residues that participate in strong (filled arrowheads) or putative (open arrowheads) interactions with EC48