Table 2.

Univariate and multivariate analyses for progression-free and overall survival

	PFS				OS
Parameters	Univariate		Multivariate		Univariate		Multivariate
	HR (95% CI)	p	HR (95% CI)	p	HR (95% CI)	p	HR (95% CI)	p
Age > 65 y	1.007 (0.983–1.032)	0.584			1.001 (0.960–1.004)	0.968
ECOG PS > 1	4.441 (1.948–10.127)	< 0.001	3.544 (1.413–8.889)	0.005	3.390 (1.161–9.898)	0.026
Visceral metastasis†	1.410 (0.723–2.752)	0.314			3.473 (0.785–15.386)	0.101
Triple-negative (ER/PR/HER2)	4.463 (1.900–10.483)	0.001	3.329 (1.328–8.342)	0.010	3.995 (1.177–13.296)	0.026
CTCs > 32/ml	1.003(1.000–1.006)	0.089			1.006 (1.003–1.010)	< 0.001	7.266 (1.775–29.741)	0.006
cCSC > 15%	2.903 (1.563–5.392)	0.001	2.867 (1.338–6.140)	< 0.0001	8.236 (2.269–29.894)	0.001	16.238 (3.167–83.264)	0.001

Abbreviations: OS: overall survival; PFS: progression-free survival; HR: hazard ratio; ECOG PS: Eastern Cooperative Oncology Group performance wtatus; ER, estrogen receptor; PR, progesterone receptor; HER2, human epidermal growth factor receptor 2; CTCs: circulating tumor cells; cCSCs: circulating cancer stem cells