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. 2019 Dec 2;14:45. doi: 10.1186/s13024-019-0346-0

Table 1.

BSC models of Aβ physiology and pathophysiology

Human Pathology Slice Culture Pathology Reference(s)
Increased levels of Aβ production BSCs from 3xTg-AD mice produce increased amounts of Aβ42 after 4 weeks in culture. BSCs from CRND8 mice also show elevated levels of Aβ42 from 2 weeks in culture. APP overexpression in non-transgenic rat cultures shows increased Aβ production by 3 days in culture. [13, 38, 44]
Thioflavin S positive plaques BSCs treated with APP23 or APPPS1 brain and supplemented with Aβ1–40 show Thioflavin S positive plaques. BSCs from adult APPSwDI show preserved Thioflavin S plaques in culture. [20, 45]
Dystrophic neurites BSCs treated with APP23 or APPPS1 brain and supplemented with Aβ1–40 develop dystrophic neurites. [45]
Gliosis BSCs from adult APPSwDI show preserved gliosis in culture. [20]
Synapse loss CRND8 BSCs develop synapse loss by 6 weeks in culture. [38]