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. 2019 Dec 2;14:45. doi: 10.1186/s13024-019-0346-0

Table 2.

BSC studies of tau physiology and pathophysiology

Human Pathology Slice Culture Pathology Reference(s)
Phosphorylated / conformationally altered tau BSCs from 3xTg-AD, JNPL3, TauRDΔK and Htau mice all develop increased levels of phosphorylated tau from 1 to 4 weeks in culture. rAAV WT, S320F, P301L/S320F and A152T/P301L/S320F human tau transduced BSCs all accumulate phosphorylated tau by 28 days in vitro (DIV). [12, 13, 29, 59]
Thioflavin S positive tau inclusions rAAV P301L/S320F and A152T/P301L/S320F human tau transduced BSCs progressively develop Thioflavin S positive tau inclusions beyond 7 DIV. TauRDΔK BSCs accumulate Thioflavin S puncta from 25 DIV. [29, 59]
Tau-induced cell loss rAAV A152T/P301L/S320F human tau transduced BSCs develop cell loss by 2 months in culture. [29]
Tau redistribution BSCs from 3xTg-AD mice show an accumulation of tau at the membrane by 28 DIV. rAAV P301L/S320F and A152T/P301L/S320F human tau transduced BSCs show somatodendritic accumulation of tau by 28 DIV. TauRDΔK BSCs accumulate tau in the somatodendritic compartment. [13, 29, 59]