Table 3.

BSC studies models of proteopathic inclusion pathologies beyond Aβ and tau

Human Pathology	Slice Culture Pathology	Reference(s)
α-synuclein inclusions	rAAV expression of WT or A53T human α-synuclein in BSCs induces pser129 α-synuclein inclusions. rAAV expression of A53T human α-synuclein in nigrostriatal circuit BSCs also develop α-synuclein inclusions.	[29, 82]
SOD-1 inclusions	SOD-1 accumulation in spinal cord slice cultures from transgenic G93A SOD-1 mice from 3 weeks in culture. SOD-1 inclusions also inducible in G85R SOD-1 transgenic spinal cord cultures with human SOD-1 seeds from spinal tissues progressively over a 20 day incubation.	[85, 86]
TDP-43 inclusions	BSCs from rats expressing human mutant TDP-43 develop TDP-43 inclusions and associated micro- and astrogliosis from 10 DIV.	[87]
Huntingtin inclusions	Biolistic transfection of human wild-type and mutant huntingtin (HTT) in striatal and cortical rat BSCs results in the development of HTT inclusions by 7 DIV.	[89]