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. 2019 Dec 2;10:5492. doi: 10.1038/s41467-019-13420-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Lower ELP5 expression is correlated with drug resistance and downregulated P53 function in GBC patients. a Drug resistance-related biological signatures were enriched GBC specimens with low ELP5 expression. b Cell cycle, DNA damage, senescence, and P53-related biological signatures were dysregulated in GBC specimens with low ELP5 expression. c Heat map of P53 target genes that were downregulated in GBC specimens with low ELP5 expression (n = 6) compared to those with high ELP5 expression (n = 4).