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. 2019 Dec 2;9:18060. doi: 10.1038/s41598-019-54475-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Summary of the RNA-Seq experiment examining the global RNA expression in the lin28b mutant fish at 1d and 7d. (A) Sampling and study design. After dissecting the anterior part from embryos/larvae, we pooled 6–10 samples together. The resulting 4–6 biological replicates per group were subjected to RNA sequencing. (B) Plots of mean logFC differences between the lin28b −/− and the +/+ fish at 1dpf (upper panel), and at 7dpf (lower panel). The genes showing significantly different expression in the global analysis (p < 0.00005, FDR < 0.1) are highlighted in red. (C,D) Results from the gene ontology analysis by GSEA, showing the GO categories differentiating between the lin28b −/− and the +/+ groups. E) Enriched GO terms in the lin28b −/− fish from the GOrilla analysis. Upper panels shows the results for the 1dpf fish and the lower panel for the 7dpf zebrafish.