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. 2019 Dec 2;9:18060. doi: 10.1038/s41598-019-54475-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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LIN28B correlations with hormonal genes in the hypothalamus and pituitary in GTEx. The figures show relative LIN28B expression on the X-axis compared to the expression of selected genes from the hypothalamus in the Y-axis (log2 TPM + 1). LIN28B expression correlated positively with all the tested genes in the hypothalamus (R = 0.58–0.70, P < 8e-10))). Particularly, the expression of ESR1 and AR was upregulated: these genes showed statistically more robust correlations with LIN28B than the majority of the other ~50000 transcripts (p-value in parenthesis). Although GNRHR, LHB and FSHB showed no correlations with LIN28B levels in the pituitary, we observed a statistically significant positive correlation between LIN28B and POMC expression (R = 0.57, P = 3e-17). The correlation with POMC was among the most robust correlations for LIN28B in the pituitary.