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. 2019 Dec 2;10:5486. doi: 10.1038/s41467-019-13114-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Redox proteomic analysis of adipocytes. a Experimental design of the redox proteomic analysis of adipocytes treated with BCNU or BCNU/AF. b Immunoblotting of Prdx2/3 dimerisation. Prdx2/3 dimer/monomer ratio was measured. Data were shown as mean ± SEM from n = 4, ****p < 0.0001 by one-way ANOVA. c Coefficient of variation of the quantified redox proteome. Boxes capture lower quartile and upper quartile with median displayed as a horizontal line in the middle; whiskers are min and max. d Principal component analysis of the redox proteome. e Relative intensities of the quantified redox proteome. f Direction-based integrative analysis of redox proteome between 2 h and 24 h treatment of BCNU/AF (see “Methods”). Significantly oxidized peptides were coloured (p < 0.01, by modified Pearson’s Correlation Test³²). g Direction pathway analysis of significantly oxidized proteins under both the 2 h and 24 h treatment of BCNU/AF (corresponding to the red dots in Fig. 1f) using gene ontology.