Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Dec 2;9:18111. doi: 10.1038/s41598-019-54308-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

PNGR altered intestinal maturation in pups at weaning. (a) Representative haematoxylin and eosin (HE) staining of ileum sections from control (CTRL) and postnatal growth restriction (PNGR) pups. (b) Crypt depth and (c) villus height in ileum at postnatal day 21 (PN21) in CTRL (n = 12 from 4 litters) and PNGR (n = 11 from 4 litters) groups. (d) Representative HE staining of colonic sections from CTRL and PNGR pups. (e) Crypt depth, (f) mucosa thickness, and (g) number of goblet cells in colon at PN21 in CTRL (n = 12 from 4 litters) and PNGR (n = 11 from 4 litters) groups. Representative staining of (h) sialylated glycans by MAA lectin and (i) fucosylated glycans by UEA1 lectin in ileum and colon at PN21 in CTRL (n = 11 from 4 litters) and PNGR (n = 10 from 4 litters) groups. (j) Representative immunostaining of occludin in ileum and colon at PN21 in CTRL (n = 9–11 from 4 litters) and PNGR (n = 8–9 from 4 litters) groups. (k) Representative immunostaining of claudin7 in ileum and colon at PN21 in CTRL (n = 9 from 4 litters) and PNGR (n = 11 from 4 litters) groups. (l) In vivo intestinal paracellular permeability to 4 kDa FITC-dextran at PN21 in CTRL (n = 12 from 4 litters) and PNGR (n = 8 from 4 litters) groups. (m–r) Cytokines expression in colon at PN21 in CTRL (n = 9–14 from 4 litters) and PNGR (n = 9–11 from 4 litters) groups. Results are representative of 2–3 independent experiments. *P < 0.05; **P < 0.01; ***P < 0.001.