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. 2019 Dec 2;9:18111. doi: 10.1038/s41598-019-54308-6

Table 1.

Taxonomic profile of fecal microbiota.

Phylum Genus CTRL PN21 vs. PNGR PN21 CTRL PN60 vs. PNGR PN60 CTRL PN21 vs. CTRL PN60 PNGR PN21 vs. PNGR PN60 Description
median PNGR median CTRL p q median PNGR median CTRL p q p q p q
Actinobacteria Atopobium 0.0 0.0 0.50 0.26 0.0 0.0 0.22 0.36 0.01 0.02 0.44 0.17 No increase during time development in PNGR
Actinobacteria Coriobacteriaceae [Uncultured] 6.18E-05 1.69E-05 0.06 0.07 0.00022 0.00035 0.36 0.44 9.44E-06 7.82E-05 1.20E-05 2.95E-05 Increase during time developmentc
Actinobacteria Enterorhabdus 0.00068 0.00125 0.19 0.16 0.00501 0.00394 0.13 0.26 2.40E-05 0.00015 8.82E-10 1.41E-08 Increase during time developmentc
Bacteroidetes Bacteroidales S24-7 group [Other] 0.0 0.0 0.32 0.21 3.35E-05 2.59E-05 0.92 0.70 0.019 0.031 0.023 0.016 Increase during time developmentc
Bacteroidetes Alistipes 0.04430 0.03529 0.30 0.20 0.06374 0.04161 0.009 0.080 0.19 0.18 0.035 0.022 Increase during time developmentb
Bacteroidetes Bacteroidales S24-7 group [Uncultured] 0.20150 0.25006 0.045 0.065 0.37349 0.39818 0.15 0.27 1.54E-09 8.94E-08 2.24E-07 1.80E-06 Increase during time developmentc
Bacteroidetes Bacteroides 0.18501 0.08674 0.0005 0.003 0.03746 0.03175 0.25 0.40 1.12E-07 2.16E-06 3.09E-09 3.30E-08 Decrease during time developmentc; Remarkably high at PN21 in PNGR
Bacteroidetes Odoribacter 0.01048 0.03219 0.011 0.024 0.02065 0.01583 0.013 0.079 0.059 0.075 0.038 0.023 Opposite time development
Bacteroidetes Parabacteroides 0.00039 0.0 0.003 0.011 0.0 2.03E-05 0.40 0.46 0.28 0.24 0.006 0.005 Remarkably high at PN21 in PNGR
Bacteroidetes Porphyromonadaceae [Uncultured] 0.0 0.0 0.63 0.30 4.04E-05 9.19E-05 0.052 0.15 6.30E-06 6.09E-05 4.73E-06 1.38E-05 Increase during time developmentc
Bacteroidetes Rikenellaceae RC9 gut group 0.04054 0.00748 0.22 0.17 0.01054 0.00479 0.027 0.11 0.10 0.11 0.038 0.023 Decrease during time developmentb
Bacteroidetes Bacteroidales [Other] 0.00010 0.00013 0.014 0.028 0.00073 0.00064 0.52 0.54 2.14E-08 6.20E-07 7.99E-07 5.12E-06 Increase during time developmentc; Repressed at PN21 in PNGR
Unclassified Bacteria [Other] 1.22E-05 9.05E-05 0.035 0.055 0.00033 0.00042 0.21 0.36 0.0002 0.0007 6.53E-05 0.0001 Increase during time developmentc
Firmicutes Clostridiales vadinBB60 group [Other] 4.89E-05 0.0 0.35 0.21 0.00150 0.00034 0.048 0.15 0.012 0.022 0.001 0.002 Increase during time developmentc
Firmicutes Lachnospiraceae [Other] 0.00054 0.00356 0.001 0.005 0.00253 0.00297 0.32 0.44 0.63 0.43 4.01E-06 1.29E-05 Repressed at PN21 in PNGR
Firmicutes Anaerotruncus 0.00483 0.00678 0.17 0.14 0.00209 0.00388 0.004 0.075 0.003 0.007 0.002 0.002 Decrease during time developmentc
Firmicutes Bacillus 0.0 1.74E-05 0.004 0.011 0.0 0.0 0.36 0.44 0.016 0.028 0.57 0.20 Premature low level in PNGR
Firmicutes Candidatus Arthromitus 0.0 0.0 0.25 0.18 0.00108 1.59E-05 0.098 0.22 0.65 0.43 0.007 0.006 Increase during time development in PNGR only
Firmicutes Clostridiales vadinBB60 group [Uncultured] 0.00082 0.00110 0.66 0.31 0.00324 0.00368 0.96 0.71 0.001 0.004 0.004 0.004 Increase during time developmentc
Firmicutes Coprococcus 1 0.00198 0.00206 0.81 0.35 0.00080 0.00092 0.41 0.46 0.0007 0.003 0.013 0.011 Decrease during time developmentc
Firmicutes Enterococcus 0.0 0.0 0.022 0.039 0.0 0.0 0.53 0.54 0.98 0.58 0.005 0.005 Remarkably high at PN21 in PNGR
Firmicutes Erysipelatoclostridium 0.00070 1.29E-05 0.003 0.011 0.00014 0.00025 0.043 0.15 0.16 0.15 0.002 0.002 Remarkably high at PN21 in PNGR
Firmicutes Erysipelotrichaceae [Uncultured] 6.18E-05 0.00016 0.40 0.23 0.00075 0.00145 0.11 0.22 0.006 0.012 0.025 0.016 Increase during time developmentc
Firmicutes Eubacterium coprostanoligenes group 0.00836 0.00127 0.0004 0.003 0.0 0.00010 0.002 0.057 0.69 0.45 2.10E-06 9.61E-06 Remarkably high at PN21 in PNGR
Firmicutes Eubacterium oxidoreducens group 0.0 0.0 0.33 0.21 2.69E-05 1.64E-05 0.37 0.44 0.35 0.28 0.0004 0.0006 Increase during time developmentb
Firmicutes Intestinimonas 0.00065 0.00012 0.023 0.039 0.00087 0.00100 0.52 0.54 0.032 0.049 0.68 0.23 Premature high level in PNGR
Firmicutes Lachnoclostridium 0.00784 0.01151 0.17 0.14 0.00593 0.00545 0.61 0.56 0.002 0.005 0.13 0.064 Decrease during time developmenta
Firmicutes Lachnoclostridium 5 2.45E-05 0.0 0.0006 0.003 0.0 8.49E-06 0.78 0.66 0.002 0.006 0.26 0.11 Premature high level in PNGR
Firmicutes Lachnospiraceae FCS020 group 0.00018 0.00103 9.02E-06 0.0004 0.00075 0.00042 0.017 0.087 0.0006 0.002 5.27E-05 0.0001 Opposite time development
Firmicutes Lachnospiraceae NK4B4 group 0.0 0.00021 6.50E-05 0.0009 5.56E-05 5.11E-05 0.55 0.54 0.037 0.052 6.50E-05 0.0001 Opposite time development
Firmicutes Lachnospiraceae UCG-001 1.03E-05 0.00010 0.28 0.20 0.01930 0.01275 0.39 0.45 3.95E-06 5.05E-05 1.89E-05 4.05E-05 Increase during time developmentc
Firmicutes Lachnospiraceae UCG-004 0.0 0.00029 0.060 0.074 0.00054 0.00051 0.62 0.57 0.024 0.037 0.002 0.002 Increase during time developmentc
Firmicutes Lachnospiraceae UCG-005 0.0 4.88E-05 0.095 0.10 0.00034 0.00021 0.68 0.62 0.005 0.012 0.003 0.003 Increase during time developmentc
Firmicutes Lachnospiraceae UCG-006 0.00139 0.00067 0.55 0.28 0.00247 0.00203 0.37 0.44 0.013 0.023 0.004 0.004 Increase during time developmentc
Firmicutes Lachnospiraceae UCG-010 0.0 8.40E-05 0.004 0.011 2.12E-05 3.22E-05 0.79 0.66 0.035 0.050 0.063 0.034 Premature low level in PNGR
Firmicutes Lachnospiraceae Incertae Sedis 0.00032 0.00247 0.044 0.065 0.00163 0.00143 0.70 0.63 0.39 0.31 0.013 0.011 Opposite time development
Firmicutes Lachnospiraceae [Uncultured] 0.03506 0.070182 0.002 0.007 0.04509 0.05166 0.37 0.44 0.10 0.11 0.22 0.096 Premature low level in PNGR
Firmicutes Marvinbryantia 0.00129 0.00198 0.23 0.17 0.006 0.00433 0.32 0.44 0.069 0.081 9.53E-05 0.0002 Increase during time developmentb
Firmicutes Roseburia 0.00528 0.01254 0.062 0.074 0.00972 0.00987 0.91 0.70 0.48 0.35 0.041 0.024 Opposite time development
Firmicutes Ruminiclostridium 5 0.00083 0.00190 0.005 0.013 0.00282 0.00364 0.31 0.44 0.051 0.068 3.18E-06 1.13E-05 Increase during time developmentb; Repressed at PN21 in PNGR
Firmicutes Ruminococcaceae NK4A214 group 8.26E-05 1.83E-05 0.44 0.25 8.46E-05 0.000523 0.0006 0.042 1.22E-05 8.84E-05 0.99 0.31 No increase during time development in PNGR
Firmicutes Ruminococcaceae UCG-005 0.0 0.0 0.95 0.40 0.0 0.00045 0.013 0.079 4.35E-06 5.05E-05 0.26 0.11 No increase during time development in PNGR
Firmicutes Ruminococcaceae UCG-010 0.0 0.0 0.17 0.14 0.0 0.00028 0.017 0.087 6.60E-05 0.0003 0.90 0.29 No increase during time development in PNGR
Firmicutes Ruminococcaceae UCG-013 0.0 0.0 0.35 0.21 0.0 0.00052 0.025 0.11 0.001 0.004 0.66 0.22 No increase during time development in PNGR
Firmicutes Ruminococcaceae UCG-014 0.00407 1.54E-05 0.005 0.012 0.00220 0.00453 0.040 0.15 0.011 0.021 0.18 0.084 Opposite time development
Firmicutes Ruminococcus gauvreauii group 0.0 2.83E-05 0.004 0.011 1.59E-05 0.0 0.082 0.21 0.006 0.012 0.049 0.028 Opposite time development
Firmicutes Staphylococcus 0.00040 2.63E-05 0.0002 0.002 1.22E-05 1.85E-05 0.28 0.43 0.84 0.53 1.89E-05 4.05E-05 Premature high level in PNGR
Firmicutes Streptococcus 0.00150 0.00028 1.80E-05 0.0004 0.00012 0.00012 1.0 0.72 5.81E-05 0.0003 4.41E-10 1.41E-08 Decrease during time developmentc; Remarkably high at PN21 in PNGR
Firmicutes Turicibacter 0.0 0.0 0.15 0.14 0.0 3.16E-05 0.011 0.079 5.04E-05 0.0003 0.13 0.064 No increase during time development in PNGR
Firmicutes Tyzzerella 0.00064 0.00086 0.54 0.28 9.44E-05 0.00011 0.78 0.66 0.084 0.096 0.0007 0.0009 Decrease during time developmentb
Firmicutes Tyzzerella 3 0.0 0.0 0.089 0.096 0.0 0.00011 0.046 0.15 0.002 0.005 0.023 0.016 Increase during time developmentc
Firmicutes Clostridiales [Other] 1.69E-05 1.47E-05 0.48 0.26 5.79E-05 4.07E-05 0.74 0.65 0.49 0.35 0.014 0.011 Increase during time developmentb
Firmicutes Firmicutes Family XIII [Eubacterium] brachy group 0.00011 7.52E-05 0.96 0.40 0.00016 0.00012 0.30 0.44 0.46 0.35 0.015 0.012 Increase during time developmentb
Firmicutes Firmicutes Family XIII [Eubacterium] nodatum group 7.88E-05 0.00015 0.77 0.35 0.0 0.00014 0.003 0.075 0.83 0.53 0.019 0.014 Decrease during time development in PNGR only
Firmicutes Firmicutes Family XIII [ClosFamily XIII AD3011 group 0.0 0.0 0.56 0.28 4.81E-05 4.08E-05 0.55 0.54 0.011 0.021 0.005 0.005 Increase during time developmentc
Firmicutes Firmicutes Family XIII [ClosFamily XIII UCG-001 2.63E-05 0.00022 0.002 0.007 0.00039 0.00049 0.36 0.44 0.004 0.011 1.74E-06 9.33E-06 Increase during time developmentc; Repressed at PN21 in PNGR
Proteobacteria Bilophila 0.00013 0.00013 0.85 0.37 0.00022 0.00052 0.008 0.08 0.001 0.004 0.45 0.17 No increase during time development in PNGR
Proteobacteria Desulfovibrio 0.01413 0.00781 0.14 0.14 0.00716 0.00978 0.10 0.22 0.91 0.57 0.008 0.007 Decrease during time development in PNGR only
Proteobacteria Escherichia-Shigella 0.00221 5.42E-05 0.008 0.017 0.0 8.51E-06 0.084 0.21 0.055 0.070 8.50E-06 2.27E-05 Remarkably high at PN21 in PNGR
Proteobacteria Oryza meyeriana [mitochondrial] 0.0 0.0 0.49 0.26 2.24E-05 0.0 0.10 0.22 0.94 0.57 0.017 0.013 Increase during time development in PNGR only
Proteobacteria Parasutterella 0.00052 0.00061 0.27 0.19 0.00166 0.00205 0.28 0.43 0.006 0.014 0.0002 0.0003 Increase during time developmentc
Tenericutes Anaeroplasma 1.31E-05 0.0004 0.073 0.083 0.00546 0.00232 0.025 0.11 0.021 0.034 0.0002 0.0003 Increase during time developmentc

Median relative abundance is reported for each genus in control (CTRL) and postnatal growth restriction group (PNGR) at postnatal day 21 (PN21) and postnatal day 60 (PN60). P-values < 0.05 and Q-values < 0.05 were regarded as significant. aTime development significant in CTRL group only, but same direction of change in PNGR group; bTime development significant in PNGR group only, but same direction of change in CTRL group; cTime development significant and in same direction in both CTRL and PNGR groups. (CTRL, n = 18 from 6 litters; PNGR, n = 18 from 6 litters) (results are representative of three independent experiments).