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. 2019 Nov 9;31:45–54. doi: 10.1016/j.molmet.2019.10.009

Figure 4.

Figure 4

FGF21 reduces body weight via reduced food intake in Siberian hamsters in short days (SD) before body weight reaches a seasonal nadir. (A) Body weight loss in response to exposure to SD. (B) Food intake, (C) body weight, (D) RER, (E) energy expenditure, (F) ambulatory activity, (G–I) UCP1 and DIO2 mRNA expression in AT, and (J) glucose uptake in the Siberian hamsters treated with FGF21 or vehicle. Data are mean ± SEM. N = 4/group. Statistical analyses conducted using two-way ANOVA, one-way ANOVA, or Students' T-test as appropriate. *p < 0.05, ***p < 0.001, ****p < 0.0001. (K) KLB expression and (L) pERK1/2 in the Siberian hamsters in LD, treated with FGF21, PF to treatment group, or exposed to SD (8 and 12 weeks, respectively). ap < 0.05 vs LD, bp < 0.05 vs SD + 8 weeks or 12 weeks, respectively.