Table 2.

Genotype distribution and haplotype frequencies of polymorphisms of TAS2R38 gene in males and females of the centenarian cohort and two control cohorts.

	Males		Females		p-valuea
	(n)	%	(n)	%
LBZ
Genotype
PAV/PAV	16	38.10	16	30.77	0.583
PAV/AVI	17	40.48	21	40.38
AVI/AVI	6	14.28	11	21.16
rare	3	7.14	4	7.69
Haplotype
PAV	50	59.52	54	51.92	0.488
AVI	30	35.72	46	44.23
rare	4	4.76	4	3.85
CY
Genotype
PAV/PAV	14	24.56	27	21.77	0.640
PAV/AVI	25	43.87	60	48.39
AVI/AVI	17	29.82	31	25
rare	1	1.75	6	4.84
Haplotype
PAV	54	47.37	116	46.77	0.764
AVI	59	51.75	126	50.81
rare	1	0.878	6	2.42
CMAE
Genotype
PAV/PAV	5	11.63	13	23.63	0.578
PAV/AVI	19	44.19	24	43.64
AVI/AVI	18	41.86	17	30.91
rare	1	2.32	1	1.82
Haplotype
PAV	30	34.89	50	45.46	0.255
AVI	55	63.95	59	53.63
rare	1	1.16	1	0.91

^ap-value derived from Fisher’s method. LBZ, Longevity Blue Zone cohort, n = 94 (males: n = 42, females: n = 52); CY, Cagliari young subjects’ cohort, n = 181 (males: n = 57, females: n = 124); CMAE, Cagliari cohort including middle-aged adults and elder adults, n = 98 (males: n = 43, females: n = 55).