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. 2019 Aug 16;121(7):522–528. doi: 10.1038/s41416-019-0546-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Waterfall plots of tumour reduction and time to best response in (a) vemurafenib monotherapy cohort and (b) cobimetinib plus vemurafenib pooled cohort, and (c) Kaplan–Meier median time to best response in patients who had a response to treatment. Bars are colour-coded to indicate whether time to best response is longer (red) or shorter (green) than the median. Dashed lines indicate the tumour reduction ranges for the quartiles used in the analyses. C + V cobimetinib plus vemurafenib, K–M Kaplan–Meier, Max%SLD maximum percentage change in the sum of longest diameters, PD progression of disease, Q quartile, TimeMax%SLD time to maximum percentage change in the sum of longest diameters, V vemurafenib