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. 2018 Jun 6;8(6):52. doi: 10.1038/s41408-018-0087-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Summary of all compounds that affected at least one population in 8227 AML cells. Red denotes decreased viability of at least 50% at the indicated concentration and blue denotes increased viability of at least 50% at the indicated concentration; experiment performed in duplicate. An ‘*’ indicates that the compound was retested. b, c Confirmation of the effect of 9 compounds shown to be preferential for CD34+ cells on b the CD15+ terminally differentiated blast population and c the CD34+ CD38− LSC-containing population. d Viability of bulk and CD34+ CD38− AML 8227 cells treated with the three cardiac glycosides, strophanthidin, digoxin and ouabain at indicated concentrations for 6 days. Data are representative of three independent experiments performed in triplicate and displays the mean ± s.d.