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. 2019 Dec 2;9:18072. doi: 10.1038/s41598-019-54061-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Volume flow waveform in the embryonic heart at the atrial inlet, the ventricular outlet and the atrioventricular (AV) junction. (B) Pressure waveform in the different cardiac structures. Pressure waveform value was taken from literature and applied at the ventricle outlet¹⁵. Pressure difference from flow simulations was then used to compute pressures in other parts of the heart. Systole and diastole in this figure refered to ventricle systole and ventricle diastole respectively.