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. 2019 Jul 13;8(4):579–594. doi: 10.1016/j.jcmgh.2019.07.001

Figure 10.

Figure 10

Up to 4 months after PDL, many remaining lesions have recombined cells and varying degrees of proliferation. (A) Two to 4 months after PDL, recombined cells as measured by EYFP were still present in lesions from some acinar control and acinar KrasG12D mice and in all duct-derived control and KrasG12D pancreata. (B) Both acinar-derived and duct-derived lesions exhibited varying levels of proliferation. (C) Many dilated lesions of all genotypes exhibited loss of epithelial integrity associated with inflammatory infiltrates distal to ligation. Image shown is Ptf1aCreERTLSL-KrasG12D pancreas 4 months after obstruction. (D) Acinar-derived lesions continued to express p21 at a much higher level than did duct-derived lesions. Squares with white centers correspond to Sox9-CreERT2 LSL-KrasG12D mice, and solid black squares correspond to CK19CreERT2LSL-KrasG12D mice. (E–G) Images showing p21 (red) and EYFP (green) in acinar control (E), acinar KrasG12D (F), and duct KrasG12D (G). p21 alone is shown in corresponding images below (E’–G’). *P < .05; **P < .01; ***P < .001.