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. 2019 Jul 13;8(4):579–594. doi: 10.1016/j.jcmgh.2019.07.001

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© 2019 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Mutant Kras induces p53 and p21 in acinar-derived but not duct-derived cells distal to duct obstruction. (A and B) Immunofluorescent labeling for p53 in Ptf1a^CreERTLSL-Kras^G12D cells (A) and in CK19^CreERT2LSL-Kras^G12D cells (B). Images were captured at identical gain and offset. (C–E) Ptf1a^CreERTLSL-Kras^G12DR26R^EYFP pancreata (C) and CK19^CreERT2LSL-Kras^G12DR26R^EYFP pancreata (D) were quantified (E) for the percent of EYFP+ cells that were also p21+ distal to ligation. *P < .05; **P < .01.