Table 1.
Mice Analyzed 2–10 Months After PDL
| Genotype | KrasG12D expression | Sex | Mo after PDL | Tail region pathology | Islets in tail |
|---|---|---|---|---|---|
| Ptf1aCreERT2R26REYFP | None | f | 4 | Normal duct epithelium | Yes |
| Ptf1aCreERT2R26REYFP | None | f | 4 | Normal duct epithelium | Yes |
| Ptf1aCreERT2R26REYFP | None | m | 4 | Normal duct epithelium | Yes |
| Ptf1aCreERT2R26REYFP | None | m | 4 | Normal duct epithelium | Yes |
| Ptf1aCreERT2LSL-KrasG12DR26REYFP | Acinar | f | 4 | Normal duct epithelium | Yes |
| Ptf1aCreERT2LSL-KrasG12DR26REYFP | Acinar | f | 4 | Normal duct epithelium | Yes |
| Ptf1aCreERT2LSL-KrasG12DR26REYFP | Acinar | f | 4 | No ducts | Yes |
| Ptf1aCreERT2LSL-KrasG12DR26REYFP | Acinar | f | 4 | Normal duct epithelium | Yes |
| Ptf1aCreERT2LSL-KrasG12DR26REYFP | Acinar | f | 4 | No ducts | Yes |
| Ptf1aCreERT2LSL-KrasG12DR26REYFP | Acinar | f | 4 | Normal duct epithelium | Yes |
| Ptf1aCreERT2LSL-KrasG12DR26REYFP | Acinar | m | 4 | No ducts | Yes |
| Ptf1aCreERT2LSL-KrasG12DR26REYFP | Acinar | m | 4 | Normal duct epithelium | Yes |
| Ptf1aCreERT2LSL-KrasG12DR26REYFP | Acinar | m | 4 | No ducts | Yes |
| Ptf1aCreERT2LSL-KrasG12DR26REYFP | Acinar | m | 4 | Normal duct epithelium | Yes |
| CK19CreERT2R26REYFP | None | m | 2 | Normal duct epithelium | Yes |
| CK19CreERT2R26REYFP | None | f | 2 | Normal duct epithelium | Yes |
| CK19CreERT2R26REYFP | None | f | 2.5 | Normal duct epithelium | Yes |
| CK19CreERT2R26REYFP | None | f | 4 | Normal duct epithelium | Yes |
| CK19CreERT2LSL-KrasG12DR26REYFP | Duct | f | 2 | Focal atypic ductal hyperplasia | Yes |
| CK19CreERT2LSL-KrasG12DR26REYFP | Duct | f | 2 | Focal atypic ductal hyperplasia | Yes |
| CK19CreERT2LSL-KrasG12DR26REYFP | Duct | m | 2.5 | CIS; focal invasion | Yes |
| CK19CreERT2LSL-KrasG12DR26REYFP | Duct | f | 3 | CIS; focal invasion | Yes |
| CK19CreERT2LSL-KrasG12DR26REYFP | Duct | m | 3 | CIS; focal invasion | Yes |
| CK19CreERT2LSL-KrasG12DR26REYFP | Duct | m | 4 | Early PDAC | Yes |
| aCK19CreERT2LSL-KrasG12DR26REYFP | Duct | m | 4 | Connective tissue only | Noa |
| Sox9-CreERT2 R26REYFP | None | m | 4 | Normal duct epithelium | Yes |
| Sox9-CreERT2 R26REYFP | None | f | 8 | No ducts | Yes |
| Sox9-CreERT2 R26REYFP | None | f | 8 | Normal duct epithelium | Yes |
| Sox9-CreERT2 R26REYFP | None | m | 8 | Normal duct epithelium | Yes |
| Sox9-CreERT2 R26REYFP | None | f | 10 | No ducts | Yes |
| Sox9-CreERT2 R26REYFP | None | f | 10 | Normal duct epithelium | Yes |
| Sox9-CreERT2 LSL-KrasG12DR26REYFP | Duct | m | 4 | Connective tissue only | Noa |
| Sox9-CreERT2 LSL-KrasG12DR26REYFP | Duct | m | 4 | Early invasion | Yes |
| Sox9-CreERT2 LSL-KrasG12DR26REYFP | Duct | f | 8 | Early PDAC | Yes |
| Sox9-CreERT2 LSL-KrasG12DR26REYFP | Duct | f | 8 | PDAC; liver metastasis | Yes |
| Sox9-CreERT2 LSL-KrasG12DR26REYFP | Duct | m | 8 | Early PDAC | Yes |
| Sox9-CreERT2 LSL-KrasG12DR26REYFP | Duct | f | 10 | PDAC | Yes |
| aSox9-CreERT2 LSL-KrasG12DR26REYFP | Duct | f | 8 | Connective tissue only | Noa |
CIS, carcinoma in situ.
a
Mice that were excluded from study because of loss of all pancreatic parenchyma distal to ligation.