Table 6.

Pi-Pi bonds (p-p bonds) formed by Bargapten, Psoralene, Psoralenoside, Germanicol acetate and standard drugs against targets: adrenergic α₁ receptor, muscranic M₁, muscranic M₃, dopaminergic D₂, calmodulin, mu-opioid, voltage gated L-Type calcium channel, histaminergic H₁, histaminergic H₂ and H⁺/K⁺ ATPase pump

Proteins	PDB ID	Bargapten		Psoralene		Psoralenoside		Germanicol acetate		Standard drugs
		π-π bonds	Amino Acids	π-π bonds	Amino Acids	π-π bonds	Amino Acids	π-π bonds	Amino Acids	π-π bonds	Amino Acids
Adrenergic α1	3538	2	TRP 295 PHE 299	1	PHE 299 CYS 181	1	VAL 168	0	–	3A	PHE 299 TRP 295 PHE 298
Muscranic M1	5CXV	2	TYR 381 TYR 106	3	TYR 404 TRP 378 CYS 407	2	ALA 363 LYS 362	0	–	1B	TYR 404
Muscranic M3	4 U14	1	TYR 506	1	TRP 503	1	TYR 1018	0	–	0C	–
Dopaminergic D2	6CM4	4	TRP 386 PHE 386 PHE 390 ASP 114	4	PHE 390 TRP 386 PHE 198 PHE 389	2	THR 412 TRP 100	1	TYR 408	4D	ASP 114 PHE 389 LEU 94 TRP 100
Calmodulin	1CTR	2	MET 124 PHE 92	1	LEU 105	2	GLU 11 MET 72	0	–	5E	MET 144 MET 145 MET 109 LEU 105 PHE 92
Calcium channel	1T3S	3	LEU 86 GLU 87	2	ARG 65 GLU 87	0	–	0	–	1F	ARG 413
Histaminergic H1	3RZE	2	ARG 97 CYS 180	2	ARG 97 CYS 180	0	–	0	–	2G	PHE 1104 GLU 1011
H+/K+ ATPase	5YLU	1	PHE 909	1	GLY 611	1	ASP 443	0	–	1H	ARG 544
Histaminergic H2	P25021	2	PHE 249 PHE 171	3	PHE 171 PHE 249 VAL 92	1	PHE 171	0	–	2I	PHE 267 VAL 268
Mu Opioid	5C1M	3	VAL 300 MET 151 TRP 293	3	TYR 494 CYS 407 TRP 378	2	THR 1142 ARG 1145	1	PHE 239	3J	ILE 296 HIS 297 TRP 293

Standard inhibitors or activators are: (A) phenoxy benzamine, (B) piranzapine, (C) atropine, (D) domperidone, (E) calmozolium, (F) verapamil, (G) pyrilimine, (H) omeprazole, (I) ranitidine and (J) loperamide. Amino acids are: ALA, alanine; GLN, glutamine; GLY, glycine; HIS, histidine; LYS, lysine; PHE, phenylalanine; SER, Serine; TRP, tryptophan and TYR, tyrosine and VAL, valine