Fig 7.

Temporal course of fixel-based metrics in areas showing FDC reduction. Fig. 7 shows how FDC changes (panel a) could stem from variations in either FD (panel b) or FC (panel c). Fixels showing a significant decrease in FDC (family-wise error corrected p < 0.05) between the second follow-up and baseline were identified, from which both FD and FC were extracted. The average fixel-based metrics were expressed as percentage changes after normalization for baseline values. Seven regions of interest–including genu, body and splenium of corpus callosum, bilateral cingulum and tapetum—are reported. FDC: fiber density and cross-section; FD: fiber density; FC: fiber-bundle cross-section.