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. 2019 Dec 3;14:279. doi: 10.1186/s13023-019-1260-9

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Temporal expression of WFS1 and cell type-specific expression of WFS1-related genes. a) Left: Mean WFS1 spatiotemporal expression (RPKM, or reads per kilobase per million) in 16 brain regions and 5 developmental time periods from the BrainSpan database (8–26 post-conception weeks (pcw), 4 months-4 years, 8 years–15 years, 18 years–23 years, and 30 years–40 years). Right: Mean WFS1 spatiotemporal expression normalized to each brain region’s expression across time. b) Cell-type specific expression in the human brain of WFS1-related genes. Gene list derived from BrainSpan database brains 8pcw-40 yrs. c) Cell-type specific expression in the human brain of WFS1-related genes, derived from the BrainCloud database (prefrontal cortex). d) Cell-type specific expression in the human brain of WFS1-related genes. Gene list derived from BrainSpan database, ages 4 months-4 years. e) Key to CSEA map. Hexagon size is scaled to gene list length, and each concentric ring corresponds with specificity index threshold (pSI) which decreases as the number of relatively enriched transcripts decreases and the remaining subset is relatively more specific. Map key reprinted with permission from [68]