TABLE 2.
Novel gene-obesity interactive loci modifying the risk of dyslipidemia identified from the meta-analysis of the Korean cohorts
| Trait | Environment | Gene | Marker | CHR | Position | MAF | A1/A2 | GWAS | G×E Interaction | Test | |
| ORD (P) | ORG (P) | ORG×E (P) | |||||||||
| Total-C | BMI | COL4A3BP | rs7733436 | 5 | 74666492 | 0.48 | C/T | 0.81 (3.88E-09) | 0.79 (4.26E-10) | 1.47 (7.32E-03) | CT1/CT2/EDG×E |
| WC | HMGCR | rs2878417 | 5 | 74617262 | 0.48 | G/A | 0.81 (4.04E-09) | 0.76 (3.07E-08) | 1.18 (1.62E-02) | CT1/CT2/EDG×E | |
| COL4A3BP | rs7733436 | 5 | 74666492 | 0.48 | C/T | 0.81 (5.38E-09) | 0.78 (1.97E-10) | 1.27 (1.13E-02) | CT1/CT2/EDG×E | ||
| WHR | HMGCR | rs7702895 | 5 | 74612893 | 0.48 | G/A | 0.81 (7.29E-09) | 0.72 (3.15E-08) | 1.22 (5.40E-03) | CT1/CT2/EDG×E | |
| HDL-C | BMI | LOC101929680/SCN1A | rs11890028 | 2 | 166943277 | 0.09 | G/T | 0.96 (4.19E-01) | 0.92 (8.78E-02) | 2.30 (2.79E-08) | CO |
| LDL-C | BMI | LOC101928271 | rs11693076 | 2 | 21140033 | 0.20 | C/T | 0.75 (1.25E-09) | 0.96 (6.54E-01) | 0.70 (6.79E-04) | CT1/CT2/EDG×E |
| WC | ANKDD1B | rs7703282 | 5 | 74906963 | 0.46 | A/C | 0.77 (7.72E-10) | 0.74 (6.12E-11) | 1.30 (2.45E-02) | CT1/CT2/EDG×E | |
| WHR | ANKDD1B | rs7703282 | 5 | 74906963 | 0.46 | A/C | 0.77 (9.08E-10) | 0.70 (4.41E-08) | 1.19 (4.57E-02) | EDG×E | |
| TG | BMI | LOC105374079/SLC12A8 | rs77008808 | 3 | 124868173 | 0.06 | T/C | 0.97 (6.37E-01) | 0.89 (9.29E-02) | 2.70 (4.33E-08) | CO |
| BUD13 | rs1558860 | 11 | 116607368 | 0.22 | A/C | 1.55 (5.10E-35) | 1.76 (1.01E-14) | 0.80 (3.27E-03) | EDG×E | ||
| WC | APOA5 | rs651821 | 11 | 116662579 | 0.29 | C/T | 1.87 (1.56E-73) | 2.01 (5.00E-47) | 0.81 (4.06E-04) | CT1/CT2/EDG×E | |
| BUD13 | rs918144 | 11 | 116633825 | 0.47 | T/C | 0.71 (4.22E-28) | 0.66 (1.47E-19) | 1.17 (7.75E-0)3 | EDG×E | ||
| WHR | BUD13 | rs180378 | 11 | 116588909 | 0.32 | A/G | 1.37 (8.00E-22 | 1.65 6.04E-18 | 0.76 1.26E-05 | DG1/CT1/CT2/EDG×E | |
| APOA5/ZPR1(ZNF259) | rs2075291 | 11 | 116661392 | 0.08 | A/C | 1.98 (8.80E-42) | 2.23 (4.26E-21) | 0.82 (2.43E-02) | CT1/CT2 | ||
| APOA5 | rs651821 | 11 | 116662579 | 0.29 | C/T | 1.86 (6.82E-73) | 2.26 (8.52E-41) | 0.74 (3.92E-06) | DG1/CT1/CT2/EDG×E | ||
| Remnant-C | BMI | BUD13 | rs7926828 | 11 | 116586423 | 0.31 | C/T | 1.35 (1.76E-18) | 1.33 (5.07E-16) | 1.37 (4.88E-02) | EDG×E |
| WC | BUD13 | rs2075295 | 11 | 116628401 | 0.47 | C/T | 0.75 1.53E-27 | 0.73 2.21E-27 | 1.16 1.16E-02 | EDG×E | |
| WHR | BUD13 | rs180378 | 11 | 116588909 | 0.32 | A/G | 1.35 (5.63E-26) | 1.47 (1.92E-15) | 0.84 (1.07E-03) | EDG×E | |
| APOA5 | rs651821 | 11 | 116662579 | 0.29 | C/T | 1.82 (1.52E-87) | 1.99 (4.07E-41) | 0.82 (1.76E-04) | CT1/CT2/EDG×E | ||
The results for each gene-obesity interaction were summarized according to the discriminators of obesity traits: BMI, WC, and WHR. Detailed results are presented in supplemental Table S3.