TABLE 3.
Contributions of gene-obesity interactive loci to abnormal lipid profiles
| Trait | Heritability (%) (SNP-Based Heritability) | Environment | Gene | Marker | A1/A2 | Contribution (%) of Genetic Variants | Total Genetic Contribution in KOR Population | ||||||
| Contribution of GWAS-Identified Loci for KOR (Number of SNPs) | Additional Contribution of Gene-Obesity Interaction (Allele Frequency in Each Ethnic Groupa) | ||||||||||||
| KOR | EAS | SAS | EUR | AMR | AFR | ||||||||
| Total-C | 35.5 (17.7–24.9) | BMI | COL4A3BP | rs7733436 | C/T | 9.5 (20) | 1.2 (0.48) | 1.2 (0.49) | 1.1 (0.41) | 1.2 (0.61) | 1.2 (0.54) | 0.3 (0.06) | 10.7 |
| WC | HMGCR | rs2878417 | G/A | 8.4 (17) | 1.3 (0.48) | 1.3 (0.50) | 1.2 (0.40) | 1.3 (0.58) | 1.3 (0.53) | 1.3 (0.57) | 10.8 | ||
| COL4A3BP | rs7733436 | C/T | 1.1 (0.48) | 1.2 (0.49) | 1.1 (0.41) | 1.2 (0.61) | 1.2 (0.54) | 0.2 (0.06) | |||||
| WHR | HMGCR | rs7702895 | G/A | 7.2 (15) | 1.9 (0.48) | 1.9 (0.49) | 1.8 (0.40) | 1.9 (0.56) | 1.9 (0.46) | 0.2 (0.03) | 9.1 | ||
| HDL-C | 34.8 (18.4–26.2) | BMI | LOC101929680/SCN1A | rs11890028 | G/T | 19.5 (31) | 0.3 (0.09) | 0.4 (0.13) | 0.8 (0.28) | 0.8 (0.29) | 0.6 (0.21) | 0.4 (0.16) | 19.8 |
| LDL-C | 31.7 (17.2–25.6) | BMI | LOC101928271 | rs11693076 | C/T | 5.5 (11) | 0.9 (0.20) | 0.9 (0.20) | 1.0 (0.22) | 1.6 (0.46) | 1.6 (0.48) | 1.7 (0.85) | 6.4 |
| WC | ANKDD1B | rs7703282 | A/C | 6.3 (14) | 1.8 (0.46) | 1.8 (0.48) | 1.7 (0.43) | 1.8 (0.62) | 1.8 (0.54) | 0.4 (0.06) | 8.1 | ||
| WHR | ANKDD1B | rs7703282 | A/C | 5.6 (12) | 2.4 (0.46) | 2.4 (0.48) | 2.4 (0.43) | 2.3 (0.62) | 2.4 (0.54) | 0.5 (0.06) | 8.0 | ||
| TG | 38.3 (18.4–26.4) | BMI | LOC105374079/SLC12A8 | rs77008808 | T/C | 48.2 (53) | 0.3 (0.06) | 0.3 (0.07) | 0.2 (0.04) | 0.0 (0.00) | 0.0 (0.00) | 0.0 (0.00) | 52.7 |
| BUD13 | rs1558860 | A/C | 4.2 (0.22) | 4.5 (0.24) | 3.8 (0.19) | 2.0 (0.09) | 2.8 (0.13) | 0.2 (0.01) | |||||
| WC | APOA5 | rs651821 | C/T | 36.6 (40) | 7.4 (0.29) | 7.3 (0.29) | 5.5 (0.19) | 2.6 (0.08) | 4.5 (0.15) | 4.8 (0.16) | 47.1 | ||
| BUD13 | rs918144 | T/C | 3.2 (0.47) | 3.0 (0.38) | 3.2 (0.56) | 3.2 (0.48) | 3.1 (0.60) | 2.9 (0.68) | |||||
| WHR | BUD13 | rs180378 | A/G | 39.3 (48) | 4.6 (0.32) | 4.7 (0.32) | 5.4 (0.60) | 5.3 (0.43) | 5.2 (0.40) | 5.4 (0.46) | 58.0 | ||
| APOA5/ZPR1(ZNF259) | rs2075291 | A/C | 3.4 (0.08) | 1.8 (0.04) | 0.5 (0.01) | 0.0 (0.00) | 0.0 (0.00) | 0.0 (0.00) | |||||
| APOA5 | rs651821 | C/T | 10.7 (0.29) | 10.7 (0.29) | 7.9 (0.19) | 3.8 (0.08) | 6.6 (0.15) | 6.9 (0.16) | |||||
| Remnant-C | 48.6 (11.3–14.2) | BMI | BUD13 | rs7926828 | C/T | 35.8 (55) | 1.3 (0.31) | 1.3 (0.32) | 1.5 (0.52) | 1.0 (0.22) | 1.1 (0.25) | 1.3 (0.31) | 37.0 |
| WC | BUD13 | rs2075295 | C/T | 36.7 (56) | 1.8 (0.47) | 1.7 (0.38) | 1.8 (0.46) | 1.4 (0.27) | 1.8 (0.44) | 1.6 (0.34) | 38.5 | ||
| WHR | BUD13 | rs180378 | A/G | 38.5 (59) | 2.4 (0.32) | 2.4 (0.32) | 2.7 (0.60) | 2.7 (0.43) | 2.7 (0.40) | 2.8 (0.46) | 47.8 | ||
| APOA5 | rs651821 | C/T | 6.9 (0.29) | 6.8 (0.29) | 5.1 (0.19) | 2.4 (0.08) | 4.2 (0.15) | 4.5 (0.16) | |||||
KOR, Korean; EAS, East Asian; SAS, South Asian; EUR, European; AMR, American; AFR, African.
a
Allele frequencies of each genetic marker in various ethnic groups were referred to the 1000 Genomes Project database (GRCh37/hg19).