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ARA is metabolized by COX, LOX (lipoxygenase), and CYP to form bioactive oxylipins. The CYP pathway produces EETs that are analgesic and anti-inflammatory. When COX-2 is expressed in HAECs, EETs can undergo further metabolism to yield the angiogenic 8,9,11-EHET. The effect is more potent when combined with sEH inhibition, which prevents the conversion of EETs to inactive DHETs.
