Table 1.
Demographic Features of Patients With idiopathic PNTM Disease, PCD, CF and Healthy Controls a
| Characteristics | Healthy controls (n = 40) | PNTM (n = 30) | PCD (n = 7) | CF (n = 10) |
|---|---|---|---|---|
| Age, mean ± SD years | 48.8 ± 11.7 | 66.0 ± 8.3 b,c,d | 40.3 ± 17.0 | 44 ± 17.8 |
| Gender (% female) | 12 (30) | 27 (90)b | 7 (100) | 6 (60) |
| Ethnicity | ||||
| Caucasian | 28 (70) | 27 (96.6) | 4 (57.1) | 10 (100) |
| African-American | 6 (15) | 0 | 0 | 0 |
| Asian | 3(8) | 1 (3.4) | 2 (28.6) | 0 |
| Hispanic | 2 (5) | 2 (6.7) | 1 (14.3) | 0 |
| Native American | 1 (3) | |||
| BMI (Kg/m2) | n.a. | 21.6 ± 3.1 | 23.3 ± 7.0 | 22.7 ± 5.7 |
| Current smoker | n.a. | 1 (3.3) | 0 | 0 |
| Ex-smoker | n.a. | 6 (20) | 0 | 2 (20) |
| NTM treatment status | ||||
| Treatment-naive | n.a. | 2 (6.7) | 1 (14.3) | 0 |
| On therapy | n.a. | 19 (63.3) | 3 (42.9) | 8 (80) |
| Off therapy | n.a. | 9 (30) | 3 (42.9) | 2 (20) |
| Respiratory pathogens | ||||
| M. abscessus | n.a. | 7 (23.3) | 3 (42.9) | 6 (60) |
| M. intracellulare | n.a. | 9 (30) | 1 (14.3) | 1 (10) |
| M. avium | n.a. | 8 (26.7) | 1 (14.3) | 2 (20) |
| MAC (unspeciated) | n.a. | 4 (13.3) | 1 (14.3) | 0 |
| Mixed NTM | n.a. | 2 (6.7) | 0 | 1 (10) |
| Radiologic features | ||||
| Nodular/bronchiectatic | n.a. | 25 (83.3) | 7 (100) | 9 (90) |
| Cavitary | n.a. | 5 (16.7) | 0 | 1 (10) |
| Severity | n.a. | |||
| Mild | n.a. | 8 (26.7) | 3 (42.9) | 2 (20) |
| Moderate | n.a. | 20 (66.7) | 3 (42.9) | 6 (60) |
| Severe | n.a. | 2 (6.7) | 1 (14.3) | 2 (20) |
| WBC (k/μl, mean ± SD) | n.a. | 7.0 ± 2.7 | 7.3 ± 2.6 | 7.7 ± 2.8 |
| Lymphocytes (k/μl) | n.a. | 1.6 ± 0.6 | 2.0 ± 1.5 | 1.8 ± 0.6 |
| Monocytes (k/μl) | n.a. | 0.6 ± 0.2 | 0.6 ± 0.2 | 0.6 ± 0.3 |
| CD3+ % (out of all PBMCs) | 59.8 ± 13.3 | 58.2 ± 8.4 | 63.0 ± 8.3 | 57.3 ± 7.1 |
| CD4+/CD3+ % | 65.6 ± 13.1 | 72.3 ± 12.1 | 63.0 ± 9.2 | 59.9 ± 10.2 |
| CD8+/CD3+ % | 26.1 ± 11.5 | 22.2 ± 10.83 | 29.1 ± 7.0 | 30.6 ± 7.8 |
| CD56+/CD3+ % | 3.6 ± 3.6 | 3.0 ± 2.0 | 5.8 ± 5.2 | 4.4 ± 2.5 |
| CD3-CD56+ (out of all PBMCs) | 9.9 ± 4.7 | 11.6 ± 4.3 | 9.2 ± 6.0 | 11.8 ± 4.4 |
| CRP (mg/L) | n.a. | 8.3 ± 24.8 | 4.1 ± 4.6 | 16.8 ± 26.1 |
Abbreviations: BMI, body mass index; CF, cystic fibrosis; CRP, C-reactive protein; MAC, Mycobacterium avium complex; n.a., not available; PCD, primary ciliary dyskinesia; PNTM, idiopathic pulmonary nontuberculous mycobacterial disease; SD, standard deviation; WBC, white blood cells.
a Data are expressed as n (%) unless otherwise specified.
b P value < .001 using one-way analysis of variance (ANOVA) test with Bonferroni adjustment for comparisons between healthy volunteers and PNTM patients.
c P value < .001 using one-way ANOVA test with Bonferroni adjustment for comparisons between PNTM patients and PCD patients.
d P value < .001 using one-way ANOVA test with Bonferroni adjustment for comparisons between PNTM patients and CF patients.