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. Author manuscript; available in PMC: 2019 Dec 3.
Published in final edited form as: J Proteome Res. 2019 Apr 8;18(5):1929–1938. doi: 10.1021/acs.jproteome.9b00086

Figure 2.

Figure 2.

SIRT4 structure and enzymatic mechanism. (A) The structure of SIRT4, as recently solved by Pannek et al. (2017). The structure revealed a SIRT4-specific channel (left) and SIRT4-loop (right, shown in yellow). (B) SIRT4 catalyzes the deacylation of its substrates using NAD+ as a cofactor, releasing nicotinamide (NAM) and resulting in the formation of an 2’-O-acyl-ADPR molecule and deacylated substrate.