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. Author manuscript; available in PMC: 2019 Dec 3.
Published in final edited form as: J Proteome Res. 2019 Apr 8;18(5):1929–1938. doi: 10.1021/acs.jproteome.9b00086

Figure 3.

Figure 3.

The link between SIRT4 and human disease. SIRT4 has been implicated in the development and progression of hyperinsulinemia and diabetes, liver disease, cancer, neurodegeneration, heart disease, aging, and pathogenic infections. Depending on the tissue type and disease, SIRT4 can be either detrimental or ameliorative to human health.