. Author manuscript; available in PMC: 2019 Dec 3.

Published in final edited form as: J Proteome Res. 2019 Apr 8;18(5):1929–1938. doi: 10.1021/acs.jproteome.9b00086

Table 1.

SIRT4 Enzymatic Activities and Substrates

Enzymatic activity	Substrates	Literature
ADP-ribosyltransferase	Glutamate dehydrogenase (GDH)	Haigis et al., 2006¹⁹
Deacetylase	Malonyl-CoA decarboxylase (MCD)	Laurent et al., 2013²²
	mtHsp60	Rauh et al., 2013²¹
	Stress-70
	NAD(P) transhydrogenase (NNT)
	Mitochondrial trifunctional protein α-subunit (MTPα)	Guo et al., 2016²³
Lipoamidase	Pyruvate dehydrogenase complex (PDH)	Mathias et al., 2014²⁵
Deacylase	Methylcrotonyl-CoA carboxylase (MCCC)	Anderson et al., 2017²⁸