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. 2019 Nov 26;10:2779. doi: 10.3389/fimmu.2019.02779

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Copyright © 2019 Monaghan, Zheng, Hu and Wan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The expression of Ly6C and CCR2 in monocytes is reduced during differentiation in the CNS. (A,B) The gene expression level of Ly6c1 (A) and Ccr2 (B) in monocytes isolated from the bone marrow (BM-Mono) or spinal cords (SC-Mono), and the monocyte-derived APCs isolated from the spinal cords (SC-APC) at days 14–15 following EAE induction. Shown are TPM values from RNA-Seq analysis. (C–E) Spinal cord cells were isolated at days 14–15 (C) or day 7 (D) following EAE induction. The expression of Ly6C and CCR2 in the CD45^hi CD11b^hi CD64⁺ Ly6G⁻ cells was determined. Shown are representative plots from three independent experiments, with a total of 10–11 animals in each time point. (E) Percentage of cells expressing Ly6C and CCR2 from individual animals is shown. ***P < 0.001.