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. 2019 Nov 26;10:2742. doi: 10.3389/fimmu.2019.02742

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Copyright © 2019 Cabral-Marques, Schimke, de Oliveira, El Khawanky, Ramos, Al-Ramadi, Segundo, Ochs and Condino-Neto.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Timeline depicting the discovery of genetic defects that cause PIDs associated with immune dysregulation. Genes are shown above the timeline by year of first reported mutation. The graphic below the timeline shows the cumulative increase of PIDs with immune dysregulation that were genetically characterized. The Y-axis represents the 40 genes associated with diseases of immune dysregulation that were discovered between 1990 and 2017 when the last IUIS phenotypic classification for PIDs was published (shown in the X-axis). The image was created using Time.Graphics (30).