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. 2019 Nov 26;10:2742. doi: 10.3389/fimmu.2019.02742

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Copyright © 2019 Cabral-Marques, Schimke, de Oliveira, El Khawanky, Ramos, Al-Ramadi, Segundo, Ochs and Condino-Neto.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Network of 40 genes that cause PIDs associated with immune dysregulation. The interactive circular graph illustrates the connections (e.g., physical interaction, common signaling pathways, co-localization.) between the causative genes and was developed using the GeneMANIA Cytoscape plugin (47). The genes were provided as a query and are represented by the blue nodes while their connections are represented by the gray lines. Related genes are closer together in the network and have more connecting lines among them.