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. 2019 Nov 26;10:2742. doi: 10.3389/fimmu.2019.02742

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Copyright © 2019 Cabral-Marques, Schimke, de Oliveira, El Khawanky, Ramos, Al-Ramadi, Segundo, Ochs and Condino-Neto.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Disease-specific flow cytometry tests for PIDs with immune dysregulation. The histograms show the normal expression of SAP and XIAP from healthy control lymphocytes (upper panels) compared with the absent expression of SAP and XIAP in lymphocytes from patients with X-linked lymphoproliferative syndrome type 1 (XLP1) and XLP2 (lower panels), respectively. The dot plot exhibits the absence of nuclear forkhead box P3 (FOXP3) expression in CD4⁺CD25⁺ regulatory T cells from patient PBMCs with immune dysregulation, polyendocrinopathy, enteropathy, X-linked inheritance syndrome (IPEX) (bottom right panel) compared with healthy control PBMCs (top right panel).