Figure 7.

Inborn errors of immunity that cause Syndromes with autoimmunity and others. The illustration demonstrates the mutated genes associated with syndromes with autoimmunity, and are shown with different colored backgrounds. To allow a better comprehension of signaling pathways, other molecules (TCR, CD3, CD28, CD80, and CD86) not associated with syndromes associated with autoimmunity are shown in white background. Nomenclature as designated by the 2017 IUIS phenotypic classification of PIDs (24). The illustration was constructed using Motifolio Drawing Toolkits (48).