Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Nov 26;10:1402. doi: 10.3389/fphar.2019.01402

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Woodward, Tesic, Stamenic, Jevtovic-Todorovic and Todorovic

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Application of lipoic acid reduces rebound action potentials in VTA GABA neurons. Representative trace (A) shows a clear, reversible decrease in rebound burst spiking after bath application of 1 mM ALA. As ALA was dissolved in EtOH as a vehicle, we bath applied 17 mM EtOH (vehicle), as well as EtOH vehicle + ALA to ensure results were not due to the effects of EtOH. As shown quantitatively in (B), **p = .0061 normalization of cumulative action potentials per cell reveals that EtOH did not affect rebound spiking activity, while ALA significantly reduced post-hyperpolarization firing. A separate group of cells was treated with 5 µM TTA-P2, which completely eliminated rebound firing in all but 1 cell, ***p = .0004 to show the effects of a selective T-channel antagonist on VTA GABA neurons. Panel (C) reveals no changes in average input resistance during application of drugs between all groups.