Table 2.
Prediction performance for 28 CiPA drugs of TMS, Bnet5×Cma x, and Dynamic Bnet.
| Performance metric | TMS | Bnet5×Cmax | Dynamic Bnet |
|---|---|---|---|
| ROC AUC (low vs. intermediate/high risk) | 0.956 | 0.959 | 0.994 |
| ROC AUC (low/intermediate vs. high risk) | 0.990 | 0.844 | 0.925 |
| R 2* | – | 0.662 | 0.878 |
| χ2 statistic† | 41.73 | 23.70 | 33.55 |
*Coefficient of determination with torsade metric score and Bnet5×Cmax or dynamic Bnet.
†Univariable logistic regression analysis to assess the correlation between the metric and the torsadogenic risk categories.