Figure 4.

Fifteen up-regulated genes in reduced gravity conditions can be connected in a gravity-response putative pathway. Large circles shown the genes detected in the first row clusters from the previous GEDI analysis (Figure 3) and small circles are candidates to be members of a shared pathway (as detected by Genemania App in Cytoscape v3.6.1). While most of the genes have unknown function, color have been used to highlight shared features among their GO properties. Solid lines shown related features as detected by Genemania app, dotted lines have been added by manual datamining comparisons. Note that four genes expressing F-box/RMI-like proteins (in red) out of 156 genes (related examples are auxin polar transport genes as TIR-1, cell wall remodeling and even cyclins) in the genome may be key in the definition of a microgravity specific pathway characterized by the highly interconnected nodes in this graph.