. Author manuscript; available in PMC: 2020 Feb 8.

Published in final edited form as: ACS Infect Dis. 2018 Dec 13;5(2):208–217. doi: 10.1021/acsinfecdis.8b00205

Table-3:

Minimum inhibitory concentrations (MICs)^a for compound 1 against various bacteria

Organism	Enoyl-ACP reductase	MIC (μM) - Palmitic acid + Palmitic acid
C. difficile CD630	FabK	16	16
C. difficile R20291	FabK	8	2
S. pyogenes ATCC 19615	FabK	<0.0625	4
C. perfringens HM310	FabV	>64	>64
B. ovatus HM222	FabI & FabK	>64	>64
L. reuteri LTH 5448	FabI	>64	>64
S. aureus Newman	FabI	>64	>64

Vancomycin’s MIC against test strains ranged from 0.25–1 μM. With exception of S. pyogenes MICs were done with addition of verapamil (100 μg/mL).