Figure 3. Reduced resting state functional connectivity in PPA compared to controls in using seed based (whole brain) analyses.
Images demonstrate areas throughout the cortex (in blue; p<0.05 FDR corrected) which are disconnected from each ROI (filled red circles) in PPA, as compared to controls. Whole-brain analyses reveals additional areas disconnected from IFG including dorsal premotor regions, manifest specifically in PPA-G. All subtypes show decreased connectivity between IFG and the temporoparietal junction. IFG = Inferior Frontal Gyrus; MTG = Middle Temporal Gyrus; ATL = Anterior Temporal Lobe. PPA = Primary Progressive Aphasia; PPA-G = Nonfluent/agrammatic variant of PPA; PPA-L = Logopenic variant of PPA; PPA-S = Semantic variant of PPA.
