Table 3 –
Correlation between functional connectivity and language measures in all PPA patients
| Node Pairs | Hemisphere | BNT | PPVT | NAT-NAVS | Rep66 |
|---|---|---|---|---|---|
| IFG-MTG | L | 0.22 | 0.07 | 0.27* | 0.30* |
| R | 0.07 | 0.05 | −0.04 | 0.06 | |
| IFG-ATL | L | 0.16 | 0.22 | −0.01 | −0.05 |
| R | 0.17 | 0.08 | −0.12 | −0.08 | |
| MTG-ATL | L | 0.38* | 0.31* | 0.01 | 0.05 |
| R | 0.15 | 0.06 | 0.03 | 0.06 | |
significant correlation p values (in order: BNT, PPVT, NATNAVS, Rep66): p = 0.05, 0.022, 0.006, 0.021, (FDR corrected). Following partial correlation, covarying the effect of cortical atrophy, correlation between NAT-NAVS and IFG-MTG (r= 0.231, p=0.026) and Rep66 and IFG-MTG (r=0.246, p=0.019) remained significant.
BNT = Boston Naming Test; PPVT= Peabody Picture Vocabulary Test; NATNAVS = Northwestern Anagram Test-Northwestern Assessment of Verbs and Sentences; Rep66 = WAB repetition score. IFGt = Inferior Frontal Gyrus; MTG = Middle Temporal Gyrus; ATL = Anterior Temporal Lobe. PPA = Primary Progressive Aphasia.