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. 2019 Nov 15;11:316. doi: 10.3389/fnagi.2019.00316

Figure 1.

Figure 1

Catalpol alleviates impairment of exploratory behavior in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice. Mice were intraperitoneally injected with catalpol (15 mg/kg/day) or vehicle (saline) for 3 days, and then administered MPTP (30 mg/kg/day; n = 11), MPTP + catalpol, or vehicle starting on day 4 for 5 days. Mice that were previously treated with MPTP + catalpol (n = 9) were continually administered catalpol for 6 days; those primed with MPTP received the vehicle for 6 days. Mice treated with the vehicle saline served as the control group (n = 10). (A) Treatment schedule. (B) Representative images of movement trials in the open field test (OFT). (C) Quantitative analysis of total distance traveled in the OFT. (D) Distance from the zone center. (E) The number of entries into the zone center in the OFT. (F,G) Time and score in the pole-climbing test. (H) The average amount of time mice remained on the rod in the Rotarod test. Data represent mean ± SEM. The P-values were calculated using a one-way analysis of variance (ANOVA). *P < 0.05 vs. vehicle group; #P < 0.05 vs. MPTP-induced group.