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. 2019 Nov 13;45(1):81–92. doi: 10.3892/ijmm.2019.4406

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effect of CBX on cytokine production in rat lung tissues treated with MCT. Images indicate the protein expression levels of IL-1β, IL-6, IL-10 and TNF-α in rat lung tissues. Pulmonary levels of IL-1β, IL-6 and TNF-α were significantly elevated in MCT-treated animals compared with the control rats. Pulmonary levels of IL-10 were decreased in MCT treated rats compared with the control group. Pro-inflammatory cytokines IL-1β, IL-6 and TNF-α were increased in MCT-induced inflammation, and CBX treatment significantly decreased the levels of these cytokines. IL-10 levels were increased in the lung tissues of the CBX-treated rats compared with the MCT-treated animals. Data are presented as the mean ± standard error of the mean of 6 rats/group. ^**P<0.01 vs. control. ^##P<0.01 vs. MCT treatment group. CBX, carbenoxolone; IL, interleukin; MCT, monocrotaline; CON, control; TNF-α, tumor necrosis factor-α.