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. 2019 Oct 31;45(1):131–140. doi: 10.3892/ijmm.2019.4390

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Copyright: © Zhu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Suppression of tumor growth by silencing the MyD88 gene in the HCT116 cells subcutaneous xenografts. Three groups (pLKO.1 and pLKO.1-sh3 groups) were subcutaneous xenografted onto nude mice. (A) The tumor growth of pLKO.1-sh3 group was significantly inhibited compared with pLKO.1 group. (B) The size of the primary tumors was measured every 4 days. Mice were sacrificed after 5 weeks. (C) The weights of tumors were weighed. Significant differences were identified between the pLKO.1 and pLKO.1-sh3 groups. (D) Immunohistochemical analysis of the expression of MyD88 in HCT116 cell subcutaneous xenograft tumors. Staining showed expression of MyD88 (×100 and ×200) in pLKO.1 and pLKO.1-sh3 groups. (E) Quantitative evaluation of the expression of MyD88. Bars show the MyD88 staining area ration/per field. Marked differences between the pLKO.1 and pLKO.1-sh3 groups were identified. ^*P<0.05, ^**P<0.01.